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Melanoma is the most common and deadly form of skin cancer. Although basic research has clarified the genetic events leading to the development of melanoma, the rate of new melanoma cases worldwide has increased over the past several decades, and as a result, it has become a leading cause of cancer mortality in Caucasians. Surgery remains the primary treatment for metastatic melanoma, and while it has improved outcomes for early stage melanoma, advanced melanoma remains a refractory disease for which there are limited therapeutic options. This review discusses the epidemiology, pathological features, molecular biology, and clinical management of melanoma, along with the available therapeutic agents for melanoma.Dietary pattern: where are we heading?
Long-term trends in diet and chronic diseases are rapidly emerging. The analyses of dietary intake patterns allow the integration of observations from different studies and the generation of patterns that summarize the association of foods with chronic diseases. The descriptive approach revealed six major dietary patterns, ranging from low to high-fat, refined, meat-based, processed, legume-based, and fish-based patterns. The analytical approach allows quantification of the association of individual foods with disease. As a consequence of the advances in statistical methodology, the relative importance of dietary factors changed. The reduction in the intake of processed meat and the emergence of whole grains seem to be related to the prevention of some chronic diseases. In contrast, the increase in the consumption of sugar-sweetened beverages and refined grains may be related to the development of certain types of cancer. UNPUBLISHED
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