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Acute myeloid leukemia (AML) patients with relapsed or refractory disease have less than 10% survival. Treatment with hydroxyurea (HU) can lead to a reduction in disease burden, but prospective studies have shown that HU-containing regimens lack efficacy. We previously described a salvage protocol containing fludarabine/HU, etoposide, cytarabine, and idarubicin (IA). We present the treatment outcome in a larger, prospective study and propose that a less toxic but more effective regimen might be achieved by substituting m-AMSA for idarubicin, enabling fludarabine/HU to be given at the same time. Patients with relapsed or refractory AML who had cytogenetically abnormal disease were considered eligible. Cytogenetic analysis was repeated after two cycles of salvage chemotherapy.

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