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【入手方法】Myocardial protection by methylprednisolone sodium succinate during the reperfusion period after cardioplegic arrest in pig hearts.
To assess the efficacy of methylprednisolone sodium succinate (MPSS), an immunosuppressant, as a cardioprotective agent, we compared the efficacy of MPSS in 8 pigs subjected to cardioplegic arrest (CP) for aortic cross-clamping and reperfusion (CP+R) and in a second group of 8 pigs subjected to CP+R with subsequent myocardial recovery and left ventricular function, without any treatment, after release of CP (CP+R+). Hemodynamics, intracardiac pressures, and left ventricular function were evaluated before and after CP. Eight pigs were used as controls. The infusion of MPSS during reperfusion (3 mg/kg/hr) improved the recovery of left ventricular function and decreased left ventricular end-diastolic pressure after CP. In the control group, left ventricular end-diastolic pressure was unchanged by CP (10.1 +/- 2.7 vs 10.3 +/- 4.3 mm Hg). In the MPSS group, it was improved after CP (7.2 +/- 1.4 vs 15.4 +/- 2.4 mm Hg). Left ventricular end-diastolic pressure was significantly reduced by CP+R+ in both the control and MPSS groups. In contrast, left ventricular end-diastolic pressure during reperfusion was significantly higher in the control group than in the MPSS group (14.5 +/- 3.2 vs 8.9 +/- 2.8 mm Hg; p Category: Creative Development
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