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WOW: i wanna stream this as a combo shockwave and flash file see what it’s like! you can also convert it to mp3 and burn it to dvd too!Evolution of viral, molecular, and virologic tools to study HIV-1 pathogenesis in humans.
This review focuses on the technical and conceptual evolution of the tools available to study the human immunodeficiency virus type 1 (HIV-1). Many studies have used naturally occurring HIV-1 in different host populations to establish certain correlates of protection or susceptibility to HIV-1 infection, acquired immunodeficiency syndrome (AIDS), or its complications. These studies have included early observations on the molecular diversity of HIV-1 strains and their selective pressures in different hosts. Because these observations were obtained largely from the early epidemic period of the HIV-1 pandemic, their value for predicting the course of contemporary HIV-1 epidemics has been questioned. In contrast, a number of molecular and virologic tools have been developed specifically for the study of contemporary HIV-1 epidemics. For example, the development of reverse transcriptase (RT) and protease nucleotide substitution and divergence-constant (DS-C) algorithms and their application to the study of contemporary HIV-1 strains have enabled detailed characterization of the biology of HIV-1 replication in vivo. Furthermore, the development of two new assays for measuring replication competence in infected cells based on the use of a dual-luciferase reporter system and a novel dual-luciferase methodology to demonstrate the release of infectious HIV-1 have begun to elucidate the relationship between host factors and HIV-1 pathogenesis. These methods may provide a means to determine whether host cell genes or biological factors can be targeted in conjunction with antiretroviral drug therapy to decrease or prevent the emergence of drug-resistant viral strains in infected individuals.Khanipur, Bani, India
Khanipur is a village in the Bani Area of Bani district, Uttar Pradesh, India. There are four post offices in Khanipur, viz., Khanipur East (main post office), Nuh Khanipur (block post office), Okhra Khanipur (independent post office) & Thakurdwar Khanipur (independent post office).
Category:Villages in Bani district, IndiaQ:
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