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Lipoprotein(a) (Lp(a)) is a major plasma apolipoprotein that is known to be raised in atherosclerotic heart disease (ADHD). This increase is found to be genetically linked to plasminogen, apolipoprotein B, or apolipoprotein AI. In this study, we determined if the level of plasma Lp(a) was raised in psoriasis. To achieve this, we developed a sensitive enzyme-linked immunosorbent assay and assessed the plasma level of apolipoprotein(a) in psoriatic patients. We studied 28 patients with chronic plaque-type psoriasis (age 38 +/- 14 years) and 14 healthy controls. No significant difference in the plasma concentration of Lp(a) was observed between patients with psoriasis and healthy controls (0.95 +/- 0.52 and 0.72 +/- 0.35 g/l respectively, P = 0.36). In both groups, the level of Lp(a) was significantly correlated with levels of apolipoprotein AI, but not with LDL cholesterol, triglycerides, or cholesterol. We concluded that unlike ADHD, Lp(a) is not a significant risk factor for atherosclerotic heart disease in psoriasis.A commuter train derailed in Vienna’s city centre this morning, sending several carriages crashing into the platform as it smashed into other trainriages.
The people on the train are now being taken to safety while police search the railway.
At least 25 people were injured, with most of the injuries said to be minor. One man is now in a serious condition in hospital.
Austrian Deputy Prime Minister Michael Spindelegger has confirmed reports that the accident was the result of a technical malfunction.
The chief of the German Federal Railway, Jochen Resch, has also confirmed that a technical fault caused the train to derail and crash into the platform.
Commuters on the moving
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